Article

Dissecting VEGF-Induced Acute Versus Chronic Vascular Hyperpermeability: Essential Roles of Dimethylarginine Dimethylaminohydrolase-1

2020-11-10

Abstract excerpt

Abnormal vascular leakiness plays crucial roles in several pathogenesis including cancer, macular degeneration, cardiovascular diseases and even in COVID-19-related pulmonary edema. Vascular endothelial cell growth factor (VEGF), also well-known as vascular permeability factor (VPF), activates VEGF receptor 2 (VEGFR2) and its downstream signaling leading to both acute and chronic vascular permeability. While many...

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Literature Corpus work: 890f1d58-5619-52e0-abe0-bd2c97b3d9ac
DOI: 10.2139/ssrn.3728095

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