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AQP1 differentially orchestrates endothelial cell senescence

23 Aug 2024

Abstract excerpt

Accumulation of senescent endothelial cells (ECs) with age is a pivotal driver of cardiovascular diseases in aging. However, little is known about the mechanisms and signaling pathways that regulate EC senescence. In this report, we delineate a previously unrecognized role of aquaporin 1 (AQP1) in orchestrating extracellular hydrogen peroxide (H2O2)-induced cellular senescence in aortic ECs. Our findings...

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PMID: 39180980
DOI: 10.1016/j.redox.2024.103317

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