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Article

VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis

4 Apr 2016

Abstract excerpt

Vascular endothelial growth factor A (VEGF-A) binding to the receptor tyrosine kinase VEGFR2 triggers multiple signal transduction pathways, which regulate endothelial cell responses that control vascular development. Multiple isoforms of VEGF-A can elicit differential signal transduction and endothelial responses. However, it is unclear how such cellular responses are controlled by isoform-specific VEGF-A-VEGFR2...

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PMID: 27044325
DOI: 10.1242/bio.017434

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