Article

AQP1 Differentially Orchestrates Endothelial Cell Senescence

2024-03-14

Abstract excerpt

Accumulation of senescent endothelial cells (ECs) with age is a pivotal driver of cardiovascular diseases in aging. However, little is known about the mechanisms and signaling pathways that regulate EC senescence. In this report, we delineate a previously unrecognized role of aquaporin 1 (AQP1) in orchestrating extracellular hydrogen peroxide (H 2 O 2 )-induced cellular senescence in aortic ECs. Our findings und...

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Literature Corpus work: 1c3c6ad8-da88-54ec-8a98-9b0a0114ec74
DOI: 10.1101/2024.03.13.584782

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