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Article

VEGF is essential for hypoxia-inducible factor-mediated neovascularization but dispensable for endothelial sprouting

22 Jul 2011

Abstract excerpt

Although our understanding of the molecular regulation of adult neovascularization has advanced tremendously, vascular-targeted therapies for tissue ischemia remain suboptimal. The master regulatory transcription factors of the hypoxia-inducible factor (HIF) family are attractive therapeutic targets because they coordinately up-regulate multiple genes controlling neovascularization. Here, we used an inducible...

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PMID: 21784979
DOI: 10.1073/pnas.1101321108

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