Article
Differential haplotype expression in class I MHC genes during SARS-CoV-2 infection of human lung cell lines.
Frontiers in immunology - 1 Jan 2022
Francisco Junior Ronaldo da Silva, Temerozo Jairo R, Ferreira Cristina Dos Santos, Martins Yasmmin, Souza Thiago Moreno L, Medina-Acosta Enrique, de Vasconcelos Ana Tereza Ribeiro
Abstract excerpt
Introduction: Cell entry of SARS-CoV-2 causes genome-wide disruption of the transcriptional profiles of genes and biological pathways involved in the pathogenesis of COVID-19. Expression allelic imbalance is characterized by a deviation from the Mendelian expected 1:1 expression ratio and is an important source of allele-specific heterogeneity. Expression allelic imbalance can be measured by allele-specific...
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