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Mutations in Complex I of the mitochondrial electron-transport chain sensitize the fruit fly ( <i>Drosophila melano</i> gaster) to ether and non-ether volatile anesthetics

2022-11-24

Abstract excerpt

The mitochondrial electron transport chain (mETC) contains molecular targets of volatile general anesthetics (VGAs), which places carriers of mutations at risk for anesthetic complications. The ND-23 60114 and mt:ND2 del1 lines of fruit flies ( Drosophila melanogaster ) that carry mutations in core subunits of Complex I of the mETC, replicate numerous characteristics of Leigh syndrome (LS) caused by orthologo...

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Literature Corpus work
88ffb674-e3d8-5a65-aa8c-1b2b3dd12be9
DOI
10.1101/2022.11.22.517557
Open publication

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Mutations in Complex I of the mitochondrial electron-transport chain sensitize the fruit fly ( <i>Drosophila melano</i> gaster) to ether and non-ether volatile anestheticsDOI 10.1101/2022.11.22.517557
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