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Article

Genetic variability affects absolute and relative potencies and kinetics of the anesthetics isoflurane and sevoflurane in Drosophila melanogaster.

Scientific reports - 5 Feb 2018

Olufs Zachariah P G, Loewen Carin A, Ganetzky Barry, Wassarman David A, Perouansky Misha

Abstract excerpt

Genetic variability affects the response to numerous xenobiotics but its role in the clinically-observed irregular responses to general anesthetics remains uncertain. To investigate the pharmacogenetics of volatile general anesthetics (VGAs), we developed a Serial Anesthesia Array apparatus to expose multiple Drosophila melanogaster samples to VGAs and behavioral assays to determine pharmacokinetic and...

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Identifiers

PMID: 29402974
DOI: 10.1038/s41598-018-20720-7
PMCID: PMC5799260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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