Genetic variability affects absolute and relative potencies and kinetics of the anesthetics isoflurane and sevoflurane in Drosophila melanogaster.

doi:10.1038/s41598-018-20720-7

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Article

Genetic variability affects absolute and relative potencies and kinetics of the anesthetics isoflurane and sevoflurane in Drosophila melanogaster.

Scientific reports - 5 Feb 2018

Olufs Zachariah P G, Loewen Carin A, Ganetzky Barry, Wassarman David A, Perouansky Misha

Abstract excerpt

Genetic variability affects the response to numerous xenobiotics but its role in the clinically-observed irregular responses to general anesthetics remains uncertain. To investigate the pharmacogenetics of volatile general anesthetics (VGAs), we developed a Serial Anesthesia Array apparatus to expose multiple Drosophila melanogaster samples to VGAs and behavioral assays to determine pharmacokinetic and...

Topics

Anesthetics, Inhalation
Animals
Drosophila melanogaster
Female
Genetic Variation
Isoflurane
Kinetics
Male
Mitochondria
Sevoflurane

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Identifiers

PMID: 29402974
DOI: 10.1038/s41598-018-20720-7
PMCID: PMC5799260

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