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Article

Mutations in Complex I of the Mitochondrial Electron-Transport Chain Sensitize the Fruit Fly (Drosophila melanogaster) to Ether and Non-Ether Volatile Anesthetics.

International journal of molecular sciences - 17 Jan 2023

Borchardt Luke A, Scharenbrock Amanda R, Olufs Zachariah P G, Wassarman David A, Perouansky Misha

Abstract excerpt

The mitochondrial electron transport chain (mETC) contains molecular targets of volatile general anesthetics (VGAs), which places carriers of mutations at risk for anesthetic complications. The ND-2360114 and mt:ND2del1 lines of fruit flies (Drosophila melanogaster) that carry mutations in core subunits of Complex I of the mETC replicate numerous characteristics of Leigh syndrome (LS) caused by orthologous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36768163
DOI: 10.3390/ijms24031843
PMCID: PMC9915120

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Mutations in Complex I of the Mitochondrial Electron-Transport Chain Sensitize the Fruit Fly (Drosophila melanogaster) to Ether and Non-Ether Volatile Anesthetics.PMID 36768163Read ↗

Mutations in Complex I of the mitochondrial electron-transport chain sensitize the fruit fly ( <i>Drosophila melano</i> gaster) to ether and non-ether volatile anestheticsSemantic proximity Read ↗

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