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Article

Mitochondrial Complex I Mutations Predispose Drosophila to Isoflurane Neurotoxicity.

Anesthesiology - 1 Oct 2020

Olufs Zachariah P G, Ganetzky Barry, Wassarman David A, Perouansky Misha

Abstract excerpt

BACKGROUND: General anesthetics influence mitochondrial homeostasis, placing individuals with mitochondrial disorders and possibly carriers of recessive mitochondrial mutations at increased risk of perioperative complications. In Drosophila, mutations in the ND23 subunit of complex I of the mitochondrial electron transport chain-analogous to mammalian NDUFS8-replicate key characteristics of Leigh syndrome, an...

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Identifiers

PMID: 32773682
DOI: 10.1097/ALN.0000000000003486
PMCID: PMC7494633

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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