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Article

Links between mutations in functionally separate arms of mitochondrial complex I and responses to volatile anesthetics.

Paediatric anaesthesia - 1 Dec 2024

Scharenbrock Amanda R, Borchardt Luke A, Olufs Zachariah P G, Wassarman David A, Perouansky Misha

Abstract excerpt

BACKGROUND: Individuals with mitochondrial defects, especially those in Complex I of the electron transport chain, exhibit behavioral hypersensitivity and toxicity to volatile anesthetics. In Drosophila melanogaster, mutation of ND23 (NDUFS8 in mammals), which encodes a subunit of the matrix arm of Complex I, sensitizes flies to toxicity from isoflurane but not an equipotent dose of sevoflurane. Also, in ND23...

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PMID: 39329243
DOI: 10.1111/pan.14999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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