Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neuronal methylome reveals CREB-associated neuro-axonal impairment in multiple sclerosis

30 May 2019

Abstract excerpt

BACKGROUND: Due to limited access to brain tissue, the precise mechanisms underlying neuro-axonal dysfunction in neurological disorders such as multiple sclerosis (MS) are largely unknown. In that context, profiling DNA methylation, which is a stable and cell type-specific regulatory epigenetic mark of genome activity, offers a unique opportunity to characterize the molecular mechanisms underpinning brain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Multiple Sclerosis Research Studies
Share to Neurogenesis and neuroplasticity mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31146783
DOI: 10.1186/s13148-019-0678-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neuronal methylome reveals CREB-associated neuro-axonal impairment in multiple sclerosisPMID 31146783Read ↗

DNA methylation changes in glial cells of the normal-appearing white matter in Multiple Sclerosis patientsSemantic proximity Read ↗

DNA methylation changes in glial cells of the normal-appearing white matter in Multiple Sclerosis patientsSemantic proximity Read ↗

Single nuclei RNAseq stratifies multiple sclerosis patients into distinct white matter glial responsesSemantic proximity Read ↗

Circulating cell-free DNA methylation profiles as noninvasive multiple sclerosis biomarkers: A proof-of-concept studySemantic proximity Read ↗

Implication of DNA methylation changes at chromosome 1q21.1 in the brain pathology of Primary Progressive Multiple SclerosisSemantic proximity Read ↗

Whole-blood methylation signatures are associated with and accurately classify multiple sclerosis disease severitySemantic proximity Read ↗

Epigenetic insights into multiple sclerosis disease progression.Semantic proximity Read ↗

From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesionsSemantic proximity Read ↗

Neuron-Specific DNA Methylation Differences in the Prefrontal Cortex in Parkinson’s DiseaseSemantic proximity Read ↗

Single-Cell Multi-Omics Map of Cell Type–Specific Mechanistic Drivers of Multiple Sclerosis LesionsSemantic proximity Read ↗

Whole-genome profiling of native 5-hydroxymethylation in human neurons with long-read sequencingSemantic proximity Read ↗

DNA methylation signatures of Multiple Sclerosis occur independently of genetic risk and are primarily attributed to B cells and monocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.