Article

Myelonets define spatiotemporal immunosuppressive programs in ovarian cancer

2026-08-31

Abstract excerpt

High-grade serous ovarian carcinoma (HGSC) responds poorly to immune checkpoint blockade, partly due to a macrophage-dominated immunosuppressive microenvironment. We integrated single-cell spatial proteomics and spatial transcriptomics across 50 HGSC tumors and applied SPACEstat to resolve higher-order immune communities and their transcriptional programs. We identified six immune community types, with macrophage-...

Identifiers and source

Literature Corpus work: 88c676f3-31b5-5b70-9c1f-56d4d5a5bcb5
DOI: 10.64898/2026.08.26.26361128

Open publication

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