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Fallopian tube single cell analysis reveals myeloid cell alterations in high-grade serous ovarian cancer

22 Jan 2024

Abstract excerpt

Most high-grade serous ovarian cancers (HGSCs) likely initiate from fallopian tube (FT) epithelia. While epithelial subtypes have been characterized using single-cell RNA-sequencing (scRNA-Seq), heterogeneity of other compartments and their involvement in tumor progression are poorly defined. Integrated analysis of human FT scRNA-Seq and HGSC-related tissues, including tumors, revealed greater immune and stromal...

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PMID: 38384837
DOI: 10.1016/j.isci.2024.108990

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