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Imaging mass cytometry-based characterisation of fibroblast subsets and their cellular niches in systemic sclerosis

23 Oct 2024

Abstract excerpt

Objectives Transcriptomic data demonstrated that fibroblasts are heterogeneous with functionally diverse subpopulations. Although fibroblasts are key effector cells of fibrotic diseases such as systemic sclerosis (SSc), they have not yet been characterised spatially at the cellular level. Here, we aimed to investigate fibroblast subpopulations using imaging mass cytometry (IMC) as a proteomic-based, spatially...

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PMID: 39442983
DOI: 10.1136/ard-2024-226336

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