Article

A Transcriptomic Atlas of Healthy Human Skin Links Regional Identity to Inflammatory Disease

2025-05-15

Abstract excerpt

<h4>ABSTRACT</h4> Human skin is not a uniform organ but a mosaic of anatomically distinct niches, with each site finely tuned to unique environmental demands and immune pressures. Yet, the molecular determinants that define these regional identities and their relationship to site-specific vulnerability to inflammatory disease remain poorly understood. Here, we generate a high-resolution single-cell atlas of human...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 557577eb-7ff6-5061-b1d8-9860335e4d6f
DOI: 10.1101/2025.05.10.653184

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Transcriptomic Atlas of Healthy Human Skin Links Regional Identity to Inflammatory DiseaseDOI 10.1101/2025.05.10.653184Read

A single-cell spatial transcriptomic census of human skin anatomySemantic proximity Read

A Targeted Spatial Transcriptomics Framework for a High-Resolution Human Skin Cell AtlasSemantic proximity Read

A single cell and spatial genomics atlas of human skin fibroblasts in health and diseaseSemantic proximity Read

Spatial transcriptomics stratifies psoriatic disease severity by emergent cellular ecosystemsSemantic proximity Read

Deconstruction of immune-mediated skin diseases defines six inflammatory subtypes.Semantic proximity Read

Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseasesSemantic proximity Read

A scRNA-seq atlas of chronic inflammatory skin diseasesSemantic proximity Read

Development of an Integrated Single-Cell and Spatial Transcriptomics Atlas of Healthy Human Skin Focusing on the Pilosebaceous UnitSemantic proximity Read

Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases.Semantic proximity Read

New insight into the role of fibroblasts in the epithelial immune microenvironment in the single-cell eraSemantic proximity Read

Spatial transcriptomics landscape of lesions from non-communicable inflammatory skin diseasesSemantic proximity Read

Hidden immune memory niches in inflammatory skin diseasesSemantic proximity Read