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Article

Lupus dermal fibroblasts are proinflammatory and exhibit a profibrotic phenotype in scarring skin disease.

JCI insight - 15 Feb 2024

Shoffner-Beck Suzanne K, Abernathy-Close Lisa, Lazar Stephanie, Ma Feiyang, Gharaee-Kermani Mehrnaz, Hurst Amy, Dobry Craig, Pandian Deepika, Wasikowski Rachael, Victory Amanda, Arnold Kelly, Gudjonsson Johann E, Tsoi Lam C, Kahlenberg J Michelle

Abstract excerpt

Fibroblasts are stromal cells known to regulate local immune responses important for wound healing and scar formation; however, the cellular mechanisms driving damage and scarring in patients with cutaneous lupus erythematosus (CLE) remain poorly understood. Dermal fibroblasts in patients with systemic lupus erythematosus (SLE) experience increased cytokine signaling in vivo, but the effect of inflammatory...

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Identifiers

PMID: 38358820
DOI: 10.1172/jci.insight.173437
PMCID: PMC10972618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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