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Article

Evaluation of bi-directional causal association between depression and cardiovascular diseases: a Mendelian randomization study.

Psychological medicine - 1 Jul 2022

Li Gloria Hoi-Yee, Cheung Ching-Lung, Chung Albert Kar-Kin, Cheung Bernard Man-Yung, Wong Ian Chi-Kei, Fok Marcella Lei Yee, Au Philip Chun-Ming, Sham Pak-Chung

Abstract excerpt

BACKGROUND: Depression and cardiovascular disease (CVD) are associated with each other but their relationship remains unclear. We aim to determine whether genetic predisposition to depression are causally linked to CVD [including coronary artery disease (CAD), myocardial infarction (MI), stroke and atrial fibrillation (AF)]. METHODS: Using summary statistics from the largest genome-wide association studies (GWAS)...

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Identifiers

PMID: 33032663
DOI: 10.1017/S0033291720003566

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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