Article

Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer’s Disease.

2020-08-19

Abstract excerpt

<title>Abstract</title> <p>BackgroundThree amino acid differences between rodent and human APP affect medically important features, including β-secretase cleavage of APP and Aβ peptide aggregation(1–3). Most rodent models for Alzheimer’s disease (AD) are, therefore, based on the human <italic>APP</italic> sequence, expressed from artificial mini-genes randomly inserted in the rodent genome. While these models mim...

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Literature Corpus work: 887a849d-f1b5-5927-af84-d59feaf529ef
DOI: 10.21203/rs.3.rs-32032/v2

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