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Article

Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits.

Acta neuropathologica communications - 14 Nov 2015

Xu Guilian, Ran Yong, Fromholt Susan E, Fu Chunhua, Yachnis Anthony T, Golde Todd E, Borchelt David R

Abstract excerpt

INTRODUCTION: Transgenic overexpression of amyloid precursor protein (APP) genes that are either entirely human in sequence or have humanized Aβ sequences can produce Alzheimer-type amyloidosis in mice, provided the transgenes also encode mutations linked to familial Alzheimer's Disease (FAD). Although transgenic mice have been produced that overexpress wild-type mouse APP, no mice have been generated that...

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Source

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Identifiers

PMID: 26566997
DOI: 10.1186/s40478-015-0252-9
PMCID: PMC4644287

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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