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Article

Specific Mutations near the Amyloid Precursor Protein Cleavage Site Increase γ-Secretase Sensitivity and Modulate Amyloid-β Production.

International journal of molecular sciences - 16 Feb 2023

Suzuki Ryota, Takahashi Haruka, Yoshida Chika, Hidaka Masafumi, Ogawa Tomohisa, Futai Eugene

Abstract excerpt

Amyloid-β peptides (Aβs) are produced via cleavage of the transmembrane region of the amyloid precursor protein (APP) by γ-secretase and are responsible for Alzheimer's disease. Familial Alzheimer's disease (FAD) is associated with APP mutations that disrupt the cleavage reaction and increase the production of neurotoxic Aβs, i.e., Aβ42 and Aβ43. Study of the mutations that activate and restore the cleavage of...

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Identifiers

PMID: 36835396
DOI: 10.3390/ijms24043970
PMCID: PMC9959964

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