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Growing old too early, automated assessment of skeletal muscle single fiber biomechanics in ageing R349P desmin knock-in mice using the <i>MyoRobot</i> technology

2019-08-19

Abstract excerpt

Muscle biomechanics is determined by active motor-protein assembly and passive strain transmission through cytoskeletal structures. The extrasarcomeric desmin filament network aligns myofibrils at the z-discs, provides nuclear-sarcolemmal anchorage and may also serve as memory for muscle repositioning following large strains. Our previous analyses of R349P desmin knock-in mice, an animal model for the human R350P...

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Literature Corpus work: 88785d42-4523-549f-81b8-7d224d3ddade
DOI: 10.1101/737973

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