Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Growing Old Too Early: Skeletal Muscle Single Fiber Biomechanics in Ageing R349P Desmin Knock-in Mice Using the MyoRobot Technology.

International journal of molecular sciences - 31 Jul 2020

Pollmann Charlotte, Haug Michael, Reischl Barbara, Prölß Gerhard, Pöschel Thorsten, Rupitsch Stefan J, Clemen Christoph S, Schröder Rolf, Friedrich Oliver

Abstract excerpt

Muscle biomechanics relies on active motor protein assembly and passive strain transmission through cytoskeletal structures. The desmin filament network aligns myofibrils at the z-discs, provides nuclear-sarcolemmal anchorage and may also serve as memory for muscle repositioning following large strains. Our previous analyses of R349P desmin knock-in mice, an animal model for the human R350P desminopathy, already...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomechanical Phenomena
Share to Cytoskeleton

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Desmin

Share to Gene Knock-In Techniques

Share to Intermediate Filaments

Share to Muscle Contraction

Share to Muscle Fibers, Skeletal

Share to Myofibrils

Source

Open in PubMed Open full text

Identifiers

PMID: 32752098
DOI: 10.3390/ijms21155501
PMCID: PMC7432536

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Growing Old Too Early: Skeletal Muscle Single Fiber Biomechanics in Ageing R349P Desmin Knock-in Mice Using the MyoRobot Technology.PMID 32752098Read ↗

Growing old too early, automated assessment of skeletal muscle single fiber biomechanics in ageing R349P desmin knock-in mice using the <i>MyoRobot</i> technologySemantic proximity Read ↗

Early signs of architectural and biomechanical failure in isolated myofibers and immortalized myoblasts from desmin-mutant knock-in mice.Semantic proximity Read ↗

Preaged remodeling of myofibrillar cytoarchitecture in skeletal muscle expressing R349P mutant desmin.Semantic proximity Read ↗

Mutation in the Core Structure of Desmin Intermediate Filaments Affects Myoblast Elasticity.Semantic proximity Read ↗

Desminopathies: pathology and mechanisms.Semantic proximity Read ↗

Desminopathies in muscle disease.Semantic proximity Read ↗

Severe myopathy mutations modify the nanomechanics of desmin intermediate filaments.Semantic proximity Read ↗

Knockdown of desmin in zebrafish larvae affects interfilament spacing and mechanical properties of skeletal muscle.Semantic proximity Read ↗

A mutation in desmin makes skeletal muscle less vulnerable to acute muscle damage after eccentric loading in rats.Semantic proximity Read ↗

Developmental Alterations in Heart Biomechanics and Skeletal Muscle Function in Desmin Mutants Suggest an Early Pathological Root for Desminopathies.Semantic proximity Read ↗

The desmin mutation R349P increases contractility and fragility of stem cell-generated muscle micro-tissuesSemantic proximity Read ↗

Desmin is a modifier of dystrophic muscle features in Mdx miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.