Article

The desmin mutation R349P increases contractility and fragility of stem cell-generated muscle micro-tissues

2021-07-24

Abstract excerpt

Desminopathies comprise hereditary myopathies and cardiomyopathies caused by mutations in the intermediate filament protein desmin that lead to severe and often lethal degeneration of striated muscle tissue. Animal and single cell studies hinted that this degeneration process is associated with massive ultrastructural defects correlating with increased susceptibility of the muscle to acute mechanical stress. The u...

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Literature Corpus work: aad835cc-447e-5fb5-a992-616c734bdcb4
DOI: 10.1101/2021.07.23.453481

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