Article

Increased remodeling and impaired adaption to endurance exercise in desminopathy

2021-10-03

Abstract excerpt

<h4>ABSTRACT</h4> Desminopathy the most common intermediate filament disease in humans. Desmin is an essential part of the filamentous network that aligns myofibrils, anchors nuclei and mitochondria, and connects the z-discs and the sarcolemma. We created a rat model with a mutation in R349P DES , analog to the most frequent R350P DES missense mutation in humans. To examine the effects of a chronic, physiologic...

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Literature Corpus work: be069607-b4eb-5eef-b587-be01b4fe6331
DOI: 10.1101/2021.10.03.462939

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