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Article

Mice expressing L345P mutant desmin exhibit morphological and functional changes of skeletal and cardiac mitochondria.

Journal of muscle research and cell motility - 1 Jan 2008

Kostareva Anna, Sjöberg Gunnar, Bruton Joseph, Zhang Shi-Jin, Balogh Johanna, Gudkova Alexandra, Hedberg Birgitta, Edström Lars, Westerblad Håkan, Sejersen Thomas

Abstract excerpt

Desmin mutations underlie inherited myopathies/cardiomyopathies with varying severity and involvement of the skeletal and cardiac muscles. We developed a transgenic mouse model expressing low level of the L345P desmin mutation (DESMUT mice) in order to uncover changes in skeletal and cardiac muscles caused by this mutation. The most striking ultrastructural changes in muscle from DESMUT mice were mitochondrial...

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Identifiers

PMID: 18563598
DOI: 10.1007/s10974-008-9139-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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