Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic dissection of the Drosophila BLOC-1 complex reveals distinctions in synaptic localization and homeostatic plasticity.

Molecular biology of the cell - 1 Oct 2025

Stark Rebecca, Dehn Caleb, Abadi Neelia, Xiong Yu, Porter Landon, Chen Xun, Dickman Dion

Abstract excerpt

Neuronal trafficking pathways must operate with high fidelity and speed, adapting to the dynamic demands of synaptic activity to maintain stable functionality. The biogenesis of lysosome-related organelles complex 1 (BLOC-1) is an attractive candidate to stabilize synaptic function during such challenges. BLOC-1 is an evolutionarily conserved protein complex composed of eight subunits involved in vesicle...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila
Share to Drosophila melanogaster

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to Homeostasis

Share to Neuromuscular Junction

Share to Neuronal Plasticity

Share to Neurons

Share to Synapses

Source

Open in PubMed Open full text

Identifiers

PMID: 40802288
DOI: 10.1091/mbc.E24-09-0392
PMCID: PMC12444909

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic dissection of the Drosophila BLOC-1 complex reveals distinctions in synaptic localization and homeostatic plasticity.PMID 40802288Read ↗

Blobby is a synaptic active zone assembly protein required for memory in Drosophila.Semantic proximity Read ↗

The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth.Semantic proximity Read ↗

Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency.Semantic proximity Read ↗

The E3 ligase Thin controls homeostatic plasticity through neurotransmitter release repressionSemantic proximity Read ↗

Neurodevelopmental disease mechanisms, primary cilia, and endosomes converge on the BLOC‐1 and BORC complexesSemantic proximity Read ↗

The Notch ligand E3 ligase, Mind Bomb1, regulates glutamate receptor localization in Drosophila.Semantic proximity Read ↗

Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1).Semantic proximity Read ↗

The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis.Semantic proximity Read ↗

Hierarchical assembly of presynaptic components in defined C. elegans synapses.Semantic proximity Read ↗

The Proteome of BLOC-1 Genetic Defects Identifies the Arp2/3 Actin Polymerization Complex to Function Downstream of the Schizophrenia Susceptibility Factor Dysbindin at the SynapseSemantic proximity Read ↗

Cell biology of the BLOC-1 complex subunit dysbindin, a schizophrenia susceptibility gene.Semantic proximity Read ↗

SIPA1L1/SPAR1 is a non-PSD protein involved in GPCR signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.