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Article

Drosophila Homolog of the Human Carpenter Syndrome Linked Gene, MEGF8, Is Required for Synapse Development and Function.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Sept 2022

Chen Shuting, Venkatesan Anand, Lin Yong Qi, Xie Jing, Neely Gregory, Banerjee Swati, Bhat Manzoor A

Abstract excerpt

Drosophila multiple epidermal growth factor-like domains 8 (dMegf8) is a homolog of human MEGF8 MEGF8 encodes a multidomain transmembrane protein which is highly conserved across species. In humans, MEGF8 mutations cause a rare genetic disorder called Carpenter syndrome, which is frequently associated with abnormal left-right patterning, cardiac defects, and learning disabilities. MEGF8 is also associated with...

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Identifiers

PMID: 35944997
DOI: 10.1523/JNEUROSCI.0442-22.2022
PMCID: PMC9480877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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