Article
Homeostatic plasticity fails at the intersection of autism-gene mutations and a novel class of common genetic modifiers.
eLife - 1 Jul 2020
Genç Özgür, An Joon-Yong, Fetter Richard D, Kulik Yelena, Zunino Giulia, Sanders Stephan J, Davis Graeme W
Abstract excerpt
We identify a set of common phenotypic modifiers that interact with five independent autism gene orthologs (RIMS1, CHD8, CHD2, WDFY3, ASH1L) causing a common failure of presynaptic homeostatic plasticity (PHP) in Drosophila. Heterozygous null mutations in each autism gene are demonstrated to have normal baseline neurotransmission and PHP. However, PHP is sensitized and rendered prone to failure. A subsequent...
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