Cortical development dynamics across autism spectrum disorder mouse models.

doi:10.1038/s41586-026-10679-1

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Cortical development dynamics across autism spectrum disorder mouse models.

Nature - 1 Aug 2026

Schwarz Lena A, Dotter Christoph P, Isaev Sergey, Lisi Michela, Malzl Daniel, Büschl Christoph, Ladstätter Sabrina, Oliveira Bárbara, Barel Matteo, Basilico Bernadette, Chintaluri Chaitanya, Gorkiewicz Sarah, Goudarzi Mohammad, Belinova Tereza, Reichl Stephan, Sendžikaitė Gintarė, Jayaram Satish Arcot, Koppensteiner Peter, Sommer Christoph, Vogels Tim P, Menche Jörg, Adameyko Igor, Kharchenko Peter V, Bock Christoph, Novarino Gaia

Abstract excerpt

Despite the functional diversity of over 100 causal genes1-3, phenotypic convergence across models may reveal common neurobiological processes in autism spectrum disorder (ASD). Here we profiled 251 samples from 11 monogenic mouse models of ASD using single-nucleus multi-omic sequencing across three developmental stages, both sexes and two brain regions. Despite genetic heterogeneity, ASD-linked mutations...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autism Spectrum Disorder

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Lineage

Share to Cerebral Cortex

Share to Gene Expression Regulation, Developmental

Share to Genetic Heterogeneity

Share to Neurons

Share to Sex Characteristics

Share to Synapses

Source

Open in PubMed Open full text

Identifiers

PMID: 42310454
DOI: 10.1038/s41586-026-10679-1
PMCID: PMC13441911

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cortical development dynamics across autism spectrum disorder mouse models.PMID 42310454Read ↗

Autism genes converge on asynchronous development of shared neuron classes.Semantic proximity Read ↗

Human brain organoids reveal accelerated development of cortical neuron classes as a shared feature of autism risk genesSemantic proximity Read ↗

Functional Neurogenomics to Dissect Disease Mechanisms Across Models.Semantic proximity Read ↗

Spatiotemporal analysis of autism gene enrichment implicates cortex, thalamus, and hypothalamusSemantic proximity Read ↗

Single Cell transcriptional analysis of <i>ex vivo</i> models of cortical and hippocampal development identifies unique longitudinal trendsSemantic proximity Read ↗

Recent progresses in molecular genetics of autism spectrum disorders.Semantic proximity Read ↗

Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypesSemantic proximity Read ↗

Integrative Single-Cell Analysis of Autism Spectrum Disorder Animal Models Reveal Convergent Transcriptomic Dysregulation Involved in Excitatory-Inhibitory Imbalance and Glial DisfunctionSemantic proximity Read ↗

Advances in behavioral genetics: mouse models of autism.Semantic proximity Read ↗

Monogenic mouse models of autism spectrum disorders: Common mechanisms and missing links.Semantic proximity Read ↗

Varying Intolerance of Gene Pathways to Mutational Classes Explain Genetic Convergence across Neuropsychiatric Disorders.Semantic proximity Read ↗

Autism genetics perturb prenatal neurodevelopment through a hierarchy of broadly-expressed and brain-specific genesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.