Article

Transcriptome-(Phospho)proteome Characterization of the Brain of a Constitutional Model of Cytoplasmic-predominant Pten Expression With Autism-Like Phenotypes

2020-11-23

Abstract excerpt

<title>Abstract</title> <p>Background<italic>PTEN</italic>, a well-studied tumor suppressor, has one of the strongest Mendelian associations with autism spectrum disorder (ASD), representing a special case in autism’s complex genetic architecture. Animal modeling for constitutional <italic>Pten</italic> mutation creates an opportunity to study how disruption of Pten affects neurobiology, providing insights that m...

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Literature Corpus work: 2005093e-a4a3-5ca8-be8d-88ce59d5f49d
DOI: 10.21203/rs.3.rs-111823/v1

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