Transcriptome-based classification in mice with ASD-risk mutations.

doi:10.1126/science.adz6688

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Article

Transcriptome-based classification in mice with ASD-risk mutations.

Science (New York, N.Y.) - 17 Sept 2026

Roh Junyeop Daniel, Jun Yukyung, Jeon Heesu, Kim Junyoung, Yi Yunho, Kim Minji, Cho Heejin, Oh Yusang, Moon Heera, Kim Jinkyeong, Kim Seongbin, Ryu Jeseung, Kang Muwon, Kim Jisoo, Kim Yeonghyeon, Jung Yewon, Yoo Taesun, Oh Hyoseon, Kim Hyosang, Jin Chunmei, Yang Yeji, Choi Gahyeon, Ahn Sunjoo, Kim Jin Young, Kang Hyojin, Bae Mihyun, Kim Eunjoon

Abstract excerpt

Autism spectrum disorder (ASD) is a neurodevelopmental condition with a strong genetic component. Large-scale human genetic studies have identified >1200 ASD-risk genes. We report a sex-balanced atlas of 1008 prefrontal RNA sequencing (RNA-seq) profiles from 17 mouse lines carrying ASD-risk mutations. Our analysis identified two opposing transcriptomic states. The two groups differed in sex bias, regional...

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Topics

Animals
Female
Male
Mice
Autism Spectrum Disorder

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Disease Models, Animal

Fluoxetine

Gene Expression Profiling

Genetic Predisposition to Disease

Mutation

Prefrontal Cortex

RNA-Seq

Single-Cell Gene Expression Analysis

Transcriptome

Atlases as Topic

Animals, Genetically Modified

Mice, Mutant Strains

Source

Open in PubMed

Identifiers

PMID: 42752124
DOI: 10.1126/science.adz6688

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