Article

Noncanonical structural requirements of neurofibromin SUMOylation reveal a folding-deficiency of several pathogenic mutants

2021-12-09

Abstract excerpt

<h4>ABSTRACT</h4> Neurofibromin (Nf1) is a large multidomain protein encoded by the tumour-suppressor gene NF1 . NF1 is mutated in a frequently occurring genetic disease, neurofibromatosis type I, and in various cancers. The best described function of Nf1 is its Ras-GTPase activity, carried out by its GAP-related domain (GRD). SecPH, another structurally well-characterized domain of Nf1, is immediately adjacent...

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Literature Corpus work: 1c0cc426-d5f1-5210-afba-d10ffb30b587
DOI: 10.1101/2021.12.09.471973

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