Article

The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure

2020-06-06

Abstract excerpt

Human heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) serves as a key regulating protein in RNA metabolism. Malfunction of hnRNPA1 in nucleo-cytoplasmic transport or dynamic phase separation leads to abnormal amyloid aggregation and neurodegeneration. The low complexity (LC) domain of hnRNPA1 drives both dynamic phase separation and amyloid aggregation. Here, we use cryo-electron microscopy to determine the a...

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Literature Corpus work: 95e619b8-524f-5475-8ea5-75d8f1918f2b
DOI: 10.1101/2020.06.05.135673

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