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Structural basis of activation of the tumor suppressor protein neurofibromin

29 Mar 2022

Abstract excerpt

Mutations in the NF1 gene cause the familial genetic disease neurofibromatosis type I, as well as predisposition to cancer. The NF1 gene product, neurofibromin, is a GTPase-activating protein and acts as a tumor suppressor by negatively regulating the small GTPase, Ras. However, structural insights into neurofibromin activation remain incompletely defined. Here, we provide cryoelectron microscopy (cryo-EM)...

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PMID: 35353986
DOI: 10.1016/j.molcel.2022.03.011

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