Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neurofibromin Structure, Functions and Regulation

27 Oct 2020

Abstract excerpt

mutations of which cause the tumor predisposition syndrome neurofibromatosis type 1 (NF1). Over the last three decades, studies of neurofibromin structure, interacting partners, and functions have shown that it is involved in several cell signaling pathways, including the Ras/MAPK, Akt/mTOR, ROCK/LIMK/cofilin, and cAMP/PKA pathways, and regulates many fundamental cellular processes, such as proliferation and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hippo pathway signaling and YAP/TAZ
Share to Neuroblastoma Research and Treatments
Share to Neurofibromatosis and Schwannoma Cases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33121128
DOI: 10.3390/cells9112365

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neurofibromin Structure, Functions and RegulationPMID 33121128Read ↗

[Neurofibromin - protein structure and cellular functions in the context of neurofibromatosis type I pathogenesis].Semantic proximity Read ↗

Emerging therapeutic targets for neurofibromatosis type 1Semantic proximity Read ↗

Neurofibromatosis Type 1: Pathology, Clinical Features and Molecular GeneticsSemantic proximity Read ↗

Biochemical and structural analysis reveals the Neurofibromin (NF1) protein forms a high-affinity dimerSemantic proximity Read ↗

Integrated Proteomics Identified Novel Activation of Dynein IC2-GR-COX-1 Signaling in Neurofibromatosis Type I (NF1) Disease Model CellsSemantic proximity Read ↗

Neurofibromatosis Type 1 RevisitedSemantic proximity Read ↗

Neurofibromatosis Type 1 (NF1) Tumor Suppressor, Neurofibromin, Regulates the Neuronal Differentiation of PC12 Cells via Its Associating Protein, CRMP-2Semantic proximity Read ↗

Neurofibromin binds to caveolin-1 and regulates ras, FAK, and AktSemantic proximity Read ↗

Noncanonical structural requirements of neurofibromin SUMOylation reveal a folding-deficiency of several pathogenic mutantsSemantic proximity Read ↗

Prosaposin: A Multifaceted Protein Orchestrating Biological Processes and DiseasesSemantic proximity Read ↗

A novel neurofibromin (NF1) interaction with the leucine-rich pentatricopeptide repeat motif-containing protein links neurofibromatosis type 1 and the French Canadian variant of Leigh's syndrome in a common molecular complex.Semantic proximity Read ↗

Neurofibromatosis 1 (von Recklinghausen Disease)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.