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Article

Cryo-EM Structure of the Full-length hnRNPA1 Amyloid Fibril.

Journal of molecular biology - 15 Sept 2023

Sharma Kartikay, Banerjee Sambhasan, Savran Dilan, Rajes Cedric, Wiese Sebastian, Girdhar Amandeep, Schwierz Nadine, Lee Christopher, Shorter James, Schmidt Matthias, Guo Lin, Fändrich Marcus

Abstract excerpt

Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) is a multifunctional RNA-binding protein that is associated with neurodegenerative diseases, such as amyotrophic lateral sclerosis and multisystem proteinopathy. In this study, we have used cryo-electron microscopy to investigate the three-dimensional structure of amyloid fibrils from full-length hnRNPA1 protein. We find that the fibril core is formed by a...

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Identifiers

PMID: 37481159
DOI: 10.1016/j.jmb.2023.168211
PMCID: PMC10530274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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