Article
Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a <i>Drosophila</i> model of Alzheimer’s disease
2019-07-18
Abstract excerpt
<h4>ABSTRACT</h4> Eukaryotic cells are complex systems containing internal compartments with specialised functions. Among these compartments, the endoplasmic reticulum (ER) plays a major role in processing proteins for modification and delivery to other organelles, whereas mitochondria generate energy in the form of ATP. Mitochondria and the ER form physical interactions, defined as mitochondria-ER contact sites...
Topics
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- Alzheimer's disease research and treatments
- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Genetic Neurodegenerative Diseases
- Genetics, Aging, and Longevity in Model Organisms
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Parkinson's Disease Mechanisms and Treatments
Identifiers and source
- Literature Corpus work
- 88602ba0-2b50-50d6-a01a-bc7b59a83239
- DOI
- 10.1101/706408
