Article

ER-mitochondria distance is a critical parameter for efficient mitochondrial Ca <sup>2+</sup> uptake and oxidative metabolism

2024-07-24

Abstract excerpt

<h4>ABSTRACT</h4> IP 3 receptor (IP 3 R)-mediated Ca 2+ transfer at the mitochondria-endoplasmic reticulum (ER) contact sites (MERCS) drives mitochondrial Ca 2+ uptake and oxidative metabolism and is linked to different pathologies, including Parkinson’s disease (PD). The dependence of Ca 2+ transfer efficiency on the ER-mitochondria distance remains unexplored. Employing molecular rulers that stabilize ER-m...

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Literature Corpus work: 5175738c-7c78-5221-8c79-1ab216cf2657
DOI: 10.1101/2024.07.24.604907

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