Article

Contact sites between endoplasmic reticulum sheets and mitochondria regulate mitochondrial DNA replication and segregation

2021-12-09

Abstract excerpt

Mitochondria are multi-faceted organelles crucial for cellular homeostasis that contain their own genome. Mitochondrial DNA (mtDNA) replication is a spatially regulated process essential for the maintenance of mitochondrial function, its defect causing mitochondrial diseases. mtDNA replication occurs at endoplasmic reticulum (ER)-mitochondria contact sites and is affected by mitochondrial dynamics: the absence of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 58125f86-2902-5fb8-a103-934483657aac
DOI: 10.1101/2021.12.09.472002

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Contact sites between endoplasmic reticulum sheets and mitochondria regulate mitochondrial DNA replication and segregationDOI 10.1101/2021.12.09.472002Read

Emr1 regulates the number of foci of the endoplasmic reticulum-mitochondria encounter structure complex.Semantic proximity Read

ESYT1 tethers the endoplasmic reticulum to mitochondria and is required for mitochondrial lipid and calcium homeostasisSemantic proximity Read

Mitochondrial ER Contacts Are Crucial for Mitophagy in YeastSemantic proximity Read

ER-mitochondria contacts promote mitochondrial-derived compartment biogenesis.Semantic proximity Read

ER-mitochondria contact sites in neurodegeneration: genetic screening approaches to investigate novel disease mechanismsSemantic proximity Read

ER-shaping proteins facilitate lipid exchange between the ER and mitochondria in S. cerevisiae.Semantic proximity Read

Impaired mitochondrial–endoplasmic reticulum interaction and mitophagy in Miro1-mutant neurons in Parkinson’s diseaseSemantic proximity Read

The p97-UBXD8 complex modulates ER-Mitochondria contact sites by modulating membrane lipid saturation and compositionSemantic proximity Read

Nucleus-Tethered Mitochondria are essential for Ca²⁺ homeostasisSemantic proximity Read

Mitochondrial fission is required for proper nucleoid distribution within mitochondrial networksSemantic proximity Read

Cellular senescence links mitochondria-ER contacts and agingSemantic proximity Read

TBC1D24 regulates mitochondria and endoplasmic reticulum-mitochondria contact sitesSemantic proximity Read