Article

The ER protein Creld regulates ER-mitochondria contact dynamics and respiratory complex 1 activity

2021-09-24

Abstract excerpt

<title>Abstract</title> <p>Dynamic contacts are formed between endoplasmic reticulum (ER) and mitochondria that enable the exchange of calcium and phospholipids. Disturbed contacts between ER and mitochondria impair mitochondrial dynamics and are a molecular hallmark of Parkinson’s disease. Cystein-rich with EGF-like domain (Creld) are ER-proteins associated with atrioventricular septal defects, but human CRELD1...

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Literature Corpus work: e729f7e2-80ef-56cd-bfd0-34f26704b6db
DOI: 10.21203/rs.3.rs-911428/v1

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