Article

Disarrangement of Endoplasmic reticulum-mitochondria communication impairs Ca <sup>2+</sup> homeostasis in FRDA

2020-03-29

Abstract excerpt

Friedreich ataxia (FRDA) is a neurodegenerative disorder characterized by neuromuscular and neurological manifestations. It is caused by mutations in gene FXN, which results in loss of the mitochondrial protein frataxin. Endoplasmic Reticulum-mitochondria associated membranes (MAMs) are inter-organelle structures involved in the regulation of essential cellular processes, including lipid metabolism and calcium sig...

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Literature Corpus work: c9c3021c-e7b0-5679-b0ee-f67fd7730770
DOI: 10.1101/2020.03.27.011528

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