Article

PADI2-mediated citrullination is required for efficient oligodendrocyte differentiation and myelination

2018-09-24

Abstract excerpt

Citrullination, the deimination of arginine residues into citrulline, has been implicated in the aetiology of several diseases. In multiple sclerosis (MS), citrullination is thought to be a major driver of pathology, through hypercitrullination and destabilization of myelin. As such, inhibition of citrullination has been suggested as a therapeutic strategy for MS. Here, in contrast, we show citrullination by pepti...

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Literature Corpus work: 177819d7-f8f4-562a-936d-135aef7a6197
DOI: 10.1101/425348

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