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Protein Citrullination in Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases

1 Jan 2024

Abstract excerpt

Protein citrullination (PC) is a posttranslational modification (PTM) that converts a peptidyl arginine into a peptidyl citrulline. Aberrant PC is a hallmark of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, prion disease, and multiple sclerosis. Common among these diseases is a dramatic increase of PC in reactive astrocytes. Some citrullinated...

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PMID: 39712644
DOI: 10.33696/neurol.5.101

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