Article
Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system.
Disease models & mechanisms - 1 Jan 2000
Musse Abdiwahab A, Li Zhen, Ackerley Cameron A, Bienzle Dorothee, Lei Helena, Poma Roberto, Harauz George, Moscarello Mario A, Mastronardi Fabrizio G
Abstract excerpt
Demyelination in the central nervous system is the hallmark feature in multiple sclerosis (MS). The mechanism resulting in destabilization of myelin is a complex multi-faceted process, part of which involves deimination of myelin basic protein (MBP). Deimination, the conversion of protein-bound arginine to citrulline, is mediated by the peptidylarginine deiminase (PAD) family of enzymes, of which the PAD2 and...
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