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Article

Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system.

Disease models & mechanisms - 1 Jan 2000

Musse Abdiwahab A, Li Zhen, Ackerley Cameron A, Bienzle Dorothee, Lei Helena, Poma Roberto, Harauz George, Moscarello Mario A, Mastronardi Fabrizio G

Abstract excerpt

Demyelination in the central nervous system is the hallmark feature in multiple sclerosis (MS). The mechanism resulting in destabilization of myelin is a complex multi-faceted process, part of which involves deimination of myelin basic protein (MBP). Deimination, the conversion of protein-bound a...

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Source

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Identifiers

PMID: 19093029
DOI: 10.1242/dmm.000729
PMCID: PMC2590822

Genes

MBP
GFAP
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19093029-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system.PMID 19093029Read ↗

PAD2 knockout reduces myelin protein aggregates, modulates neuroinflammation and protects motor neurons, axons and neuromuscular junction in a SOD1-ALS mouse modelSemantic proximity Read ↗

PADI2-mediated citrullination is required for efficient oligodendrocyte differentiation and myelinationSemantic proximity Read ↗

Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosisSemantic proximity Read ↗

Methylation-dependent PAD2 upregulation in multiple sclerosis peripheral bloodSemantic proximity Read ↗

Peptidylarginine deiminase expression and activity in PAD2 knock-out and PAD4-low mice.Semantic proximity Read ↗

The Role of Citrullinated Proteins Suggests a Novel Mechanism in the Pathogenesis of Multiple SclerosisSemantic proximity Read ↗

Peptidylarginine Deiminase 2 in Host Immunity: Current Insights and PerspectivesSemantic proximity Read ↗

PAD2 Overexpression in Transgenic Mice Promotes Spontaneous Skin NeoplasiaSemantic proximity Read ↗

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Deletion of indoleamine 2,3 dioxygenase (Ido)1 but not Ido2 exacerbates disease symptoms of MOG35-55-induced experimental autoimmune encephalomyelitisSemantic proximity Read ↗

Peptidylarginine deiminase 2 suppresses inhibitory {kappa}B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophages.Semantic proximity Read ↗

The glycosyltransferase EXTL2 promotes proteoglycan deposition and injurious neuroinflammation following demyelination.Semantic proximity Read ↗

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