Article

Citrullination of TDP-43 is a key post-translation modification associated with structural and functional changes and progressive pathology in TDP-43 mouse models and human proteinopathies

2025-03-02

Abstract excerpt

TAR DNA-binding protein 43 (TDP-43) pathology is associated with a spectrum of clinical dementias including limbic-predominant age-related TDP-43 encephalopathy neuropathological changes (LATE-NC). Post-translational modifications (PTM) are linked to TDP-43 toxic gain-of-function and cytoplasmic aggregation 1–3 . Phosphorylation remains the most investigated PTM and a standard criterion for determining pathology...

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Literature Corpus work: 71efc997-62bd-582c-a8ad-b92aebfc5d1d
DOI: 10.1101/2025.02.28.639952

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