Article

MYC and AP-1 oncogenes synergistically bind enhancers to rewire transcription

2025-04-29

Abstract excerpt

The transcription factor c-MYC (MYC) is deregulated in about 70% of human cancers. Through de novo motif discovery analysis on published MYC ChIP-seq datasets from cancer cell lines, we found cell-type specific co-enrichment of the TRE motifs (AP-1 binding sites), alongside MYC’s canonical EBOX motif. TRE motifs serve as indirect MYC binding sites in synergy with AP-1, predominantly at enhancers rather than promo...

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Literature Corpus work: 880967f1-b5d9-5a31-b69c-5ee0ab011b6b
DOI: 10.1101/2025.04.28.650480

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