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<i>ABCA7</i> rs3752231 variant effects on glial responses to amyloid-β and plaque maturation in Alzheimer’s disease

2026-06-23

Abstract excerpt

Variants in ABCA7 are among the most consistently replicated genetic risk factors for late-onset Alzheimer’s disease (AD), yet the cellular mechanisms remain poorly defined. Here, we characterise the impact of the common ABCA7 rs3752231 risk variant on amyloid-β (Aβ) pathology and glial responses in human post-mortem brain, combining quantitative neuropathology of 4G8-immunostained mid-temporal gyrus from 99 do...

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Literature Corpus work
87fbdd32-128e-5c83-8c39-bb833a65df2c
DOI
10.64898/2026.06.18.733103
Open publication

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