Article
The intricate cellular ecosystem of human peripheral veins as revealed by single-cell transcriptomic analysis.
PloS one - 1 Jan 2024
Rojas Miguel G, Zigmond Zachary M, Pereira-Simon Simone, Santos Falcon Nieves, Suresh Kumar Maya, Stoyell-Conti Filipe F, Kosanovic Christina, Griswold Anthony J, Salama Alghidak, Yang Xiaofeng, Tabbara Marwan, Vazquez-Padron Roberto I, Martinez Laisel
Abstract excerpt
The venous system has been historically understudied despite its critical roles in blood distribution, heart function, and systemic immunity. This study dissects the microanatomy of upper arm veins at the single cell level, and how it relates to wall structure, remodeling processes, and inflammatory responses to injury. We applied single-cell RNA sequencing to 4 non-diseased human veins (3 basilic, 1 cephalic)...
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