Article

Spatial gene expression of human coronary arteries revealed the molecular features of diffuse intimal thickening in explanted hearts

2025-01-28

Abstract excerpt

<h4>Background</h4> Diffuse intimal thickening (DIT) is a pre-clinical stage of atherosclerosis characterized by thickened intima. The molecular basis of its susceptibility to atherogenesis is unknown, and mechanistic investigations cannot be performed in commonly used mouse models, in which DIT does not exist. Vascular smooth muscle cells (SMCs) are the predominant cell type that occupies the intima and media of...

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Literature Corpus work: 444813d8-3019-5a7f-8cc3-472f826260ff
DOI: 10.1101/2025.01.20.633995

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